TOC
什么是Phenome-wide association studies？产生背景
PheWAS的基本原理，应用场景
PheWAS与GWAS的区别和联系
PheWAS实例
什么是Phenome-wide association studies？产生背景
More recently, phenome-wide association studies (PheWAS) have been used to interrogate with which phenotypes a given genetic variant may be associated (Denny et al., 2010).
PheWAS的基本原理，应用场景
Phenome-wide association studies (PheWAS) have been used to replicate known genetic associations and discover new phenotype associations for genetic variants.
PheWAS与GWAS的区别和联系
GWAS是给定phenotype，检验所有的variants。
PheWAS是给定variant，检验所有的phenotypes。
PheWAS实例
PheWAS plot for a SNP or gene can be created across GWAS in the database.
https://atlas.ctglab.nl/PheWAS
随便搜索一个基因或SNP：Sox10、rs13238909
会得到我们的基因或SNP与哪个trait最相关，需要非常大的数据库才能做这个分析。
学会了GWAS，理解PheWAS就毫无压力了。
参考：
R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment