(A)期刊論文 1. Y-H Ma, S-Y Chen, S-J Tu, H-W Yang, H-L Liu, “Manipulation of magnetic nanoparticle retention and hemodynamic consequences in microcirculation: assessment by laser speckle imaging,” International Journal of Nanomedicine, Vol. 7, pp. 1–11, 2012 (IF = 4,976,18/252 in "Pharmacology & Pharmacy") 2. C-J Ke, Y-J Lin, Y-C Hua, W-L Chiang, K-J Chen, W-C Yang, H-L Liu, C-C Fu, H-W Sung, “Multidrug release based on microneedle arrays filled with pH-responsive PLGA hollow microspheres,” Biomaterials, Accepted, 2012. (IF = 7.882, 2/69 in “Engineering, Biomedical”). 3. A-H Liao, H-L Liu**, C-H Su, M-Y Hua, H-W Yang, Y-T Weng, P-H Hsu, S-M Huang, S-Y Wu, H-El Wang, T-C Yen and P-C Li, “Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for the Induction of Focused-Ultrasound-Induced Blood–Brain Barrier Opening and Concurrent MR and Ultrasound Imaging,” Physics in Medicine and Biology, Vol. 57, pp.2787-2802, 2012 (**共同第一作者; IF = 3.056, 11/69 in “Engineering, Biomedical”) 4. K-C Wei, H-C Tsai, Y-J Lu, H-W Yang, M-Y Hua, M-F Wu, P-Y Chen, C-Y Huang, T-C Yen, and H-L Liu*, “Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine,” American Journal of Neuroradiology, Accepted, 2012. (IF=3.464, 20/111 in “Radiology”) 5. P-H Tsui, Y-C Shu, W-S Chen, H-L Liu, I-T Hsiao, and Y-T Chien, "Ultrasound temperature estimation based on probability variation of backscatter data", Medical Physics, Vol. 39, No. 5, pp. 2369-2385, 2012 (IF=3.07, 27/111 in “Radiology”). 6. P-H Wang**, H-L Liu**, P-H Hsu, C-R C Wang, P-Y Chen, K-C Wei, T-C Yen, and M-L Li, "Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused- ultrasound induced blood-brain barrier opening in a rat model", Journal of Biomedical Optics, Vol. 17, No. 6, pp. 061222, 2012 (**共同第一作者; IF=3.188, 8/78 in “Optics”). 7. C-H Fan, H-L Liu, C-Y Huang, Y-J Ma, T-C Yen, C-K Yeh, “Detection of intracerebral hemorrhage and transient blood-supply shortage in focused ultrasound-induced blood-brain-barrier disruption by ultrasound imaging,” Ultrasound in Medicine and Biology, Accepted, 2012 (IF=2.493, 4/29 in “Acoustics”). 8. P-H Tsui, Y-T Chien, H-L Liu, Y-C Shu, W-S Chen, “Using ultrasound CBE imaging without echo shift compensation for temperature estimation,” Ultrasonics, Accepted, 2012.(IF=1.599, 7/29 in “Acoustics”) 9. H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, S-T Pang, P-H Hsu, H-J Tang, T-C Yen, C-K Chuang, “An epirubicin-conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer,” Biomaterials, Vol. 33, pp. 3919-3930, 2012.(**共同第一作者; IF = 7.882, 2/69 in “Engineering, Biomedical”). 10. H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, C-K Chuang, P-C Chu,P-Y Wu, Y-H Chang,H-C Chuang, K-J Yu, and S-T Pang, “Cooperative dual-activity targeted nanomedicine for specific and effective prostate cancer therapy”, ACS Nano, Vol.6, No. 2, pp1795-1805, 2012, 2012 (**共同第一作者; IF=9.865, Filtered by Materials Science, 9/225). 11. Y-C Lin, T-H Chan, C-Y Chi, S-H Ng, H-L Liu, K-C Wei, Y-Y Wei, C-C Wang, J-J Wang, “Blind Estimation of Arterial Input Function in Dynamic Contrast-Enhanced MRI using Purity Maximization,” Magnetic Resonance in Medicine, Accepted, 2012 (IF=3.267, Rank: 21/111 in "Radiology") 12. H-L Liu, H-W Yang, M-Y Hua, and K-C Wei, “Enhanced Therapeutic Agent Delivery via MRI-Monitored Focused Ultrasound Blood-Brain Barrier Disruption for Brain Tumor Treatment: An Overview of the current Preclinical Status,” Neurosurgical Focus, Vol. 32, No. 1, E4, 2012 (IF = 2.348, 43/187 in “Surgery”). 13. C-Y Ting, C-H Fan, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh*, “Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment,” Biomaterials, Vol. 33, pp. 704-712, 2012 (*Co-corresponding author, IF = 7.882, 2/69 in “Engineering, Biomedical”). 14. M-T Tsai, T-D Chi, H-L Liu, F-Y Chang, C-H Yang, C-K Lee, and C-C Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express, Vol. 4, pp.097001-3, 2011 (IF =2.747). 15. W-S Chen, H-L Liu, Y.S. Tung, J.C. Wang, Y.H. Ding, C.K. Jan, “Reducing lesion aberration by dual-frequency focused ultrasound ablations,” International Journal of Hyperthermia, Vol. 27, No. 7, pp. 637-647, 2011 (IF=2.929, 31/111 in “Radiology”). 16. C-J Ke, T-Y Su, H-Chen, H-L Liu, W-L Chiang, P-C Chu, Y Xia, H-W Sung, “Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments,” Angewandte Chemie International Edition, Vol. 50, No. 35, pp. 8086 – 8089, 2011 (IF = 12.73, 5/144 in “Chemistry, Multidisciplinary”) 17. M-Y Hua**, H-W Yang**, H-L Liu**, R-Y Tsai, S-T Pang, K-L Chuang, Y-S Chang, T-L Hwang, Y-H Chang, H-C Chuang, C-K Chuang, “Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy,” Biomaterials, Vol. 32, pp. 8999-9910, 2011 (**共同第一作者, IF = 7.882, 2/69 in “Engineering, Biomedical”). 18. J-J Wang , W-Y Lin, C-S Lu, Y-H Weng, S-H Ng , C-H Wang , H-L Liu, R-H Hsieh , Y-L Wan, and Y-Y Wai, “Parkinson Disease_Diagnostic Utility of Diffusion Kurtosis Imaging,”Radiology, Vol. 261, No. 1, pp. 210-217 (IF=6.066, 2/111 in “Radiology”). 19. H-L Liu, P-Y Chen, H-W Yang, J-S Wu, I-C Tseng, Y-J Ma, C-Y Huang, H-C Tsai, S-M Chen, Y-J Lu, C-Y Huang, M-Y Hua, Y-H Ma, T-C Yen and K-C Wei, “In Vivo MR Quantification of Superparamagnetic Iron Oxide Nanoparticle Leakage During Low-frequency-ultrasound–induced Blood–Brain Barrier Opening In Swine,” Journal of Magnetic Resonance Imaging, Vol. 34, No. 12, pp. 1313-1324, 2011 (IF=2.770, 37/111 in “Radiology”). 20. H-W Yang**, M-Y Hua**, H-L Liu**, C-Y Huang, R-Y Tsai, Y-J Lu, J-Y Chen, H-J Tang, H-Y Hsien, Y-S Chang, T-C Yen, P-Y Chen and K-C Wei, “Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas,” Biomaterials, Vol. 32, pp. 6523-6532, 2011 (**共同第一作者, IF = 7.882, 2/69 in “Engineering, Biomedical”). 21. W-S Chen, C-C Shen, C-T Ko, C-H Cheng, H-L Liu, M-C Ho, C-N Chen, C-K Yeh, “Single-Element Ultrasound Transducer for Combined Vessel Localization and Ablation,”IEEE Trans. Ultrason. Ferroelectrics Freq. Contr., Vol. 58, No. 4, pp. 766-775, 2011 (IF = 1.46, 9/29 in “Acoustics”) 22. H-L Liu, M-L Li, P-H Tsui, M-S Lin, S-M Huang, and J Bai, “An Unified Approach to Combine Temperature Estimation and Elastography for Thermal Lesion Determination in Focused Ultrasound Thermal Therapy,” Physics in Medicine and Biology, Vol. 56, pp. 169-186, 2011. (IF = 3.056, 11/69 in “Engineering, Biomedical”) 23. M-Y Hua**, H-L Liu**, H-W Yang, P-Y Chen, R-Y Tsai, C-Y Huang, I-C Tseng, L-A Lyu, C-C Ma, H-J Tang, T-C Yen, K-C Wei, The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas, Biomaterials, Vol. 32, pp. 512-523, 2011 (**共同第一作者, IF = 7.882, 2/69 in “Engineering, Biomedical”). 24. H-L Liu, S-M Huang, and M-L Li, “High frame rate ultrasound monitoring of high intensity focused ultrasound induced temperature changes: a novel asynchronous approach,” Medical Physics, Vol. 37, No. 11, pp. 5921-5928, 2010 (IF=3.07, 27/111 in “Radiology”). 25. H-L Liu, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, J-S Wua, I-C Tseng, J-J Wang, T-C Yen, P-Y Chen, and K-C Wei, “Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain,”Proceedings of National Academy of Science USA, Vol. 107, No. 34, pp.15205-15210, 2010 (IF=9.771, 3/57 in “Multidisciplinary sciences”). 26. K-C Ju and H-L Liu, “Zero-crossing-tracking technique for noninvasively ultrasonic temperature estimation,” Journal of Ultrasound in Medicine, Vol. 29, pp.1607–1615, 2010 (IF=1.246, 11/29 in “Acoustics”). 27. P-Y Chen, H-L Liu**, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, L-A Lyu, H-C Tsai, S-M Chen, Y-J Lu, J-J Wang, T-C Yen, Y-H Ma, T. Wu, J-P Chen, J-I Chuang, J-W Shin, C. Hsueh, and K-C Wei, “Novel Magnetic/Ultrasound Focusing System Enhances Nanoparticle Drug Delivery for Glioma Treatment,” Neuro-oncology, Vol. 12, No. 10, pp.1050-1060, 2010 (**共同第一作者, IF=5.483, 15/185 in “Clinical Neurology”). 28. H-L Liu, M-Y Hua, P-Y Chen, P-C Chu, C-H Pan, H-W Yang, C-Y Huang, J-J Wang, T-C Yen and K-C Wei, “Blood–Brain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment,” Radiology, Vol. 255, No. 2, pp. 415-425, 2010 (IF=6.066, 2/111 in “Radiology”) 29. H-L Liu, C-L Hsu, S-M Huang and Y-W Hsi, “Focal Beam Distortion and Treatment Planning for Transrib Focused Ultrasound Thermal Therapy: A Feasibility Study Using a Two-dimensional Ultrasound Phased Array,” Medical Physics, Vol. 37, No. 2, pp. 848-860, 2010 (IF=3.07, 27/111 in “Radiology”). 30. H-L Liu, C-H Pan, C-Y Ting and M-J Hsiao, “Opening of the Blood-Brain Barrier By Low-Frequency (28-kHz) Ultrasound: A Novel Pinhole-Assisted Mechanical Scanning Device,” Ultrasound in Medicine and Biology, Vol. 36, No. 2, pp. 325-335, 2010(IF=2.493, 4/29 in “Acoustics”). 31. Y-C Lin, C-C Wang, Y-Y Wai, Y-L Wan,S-H Ng, Y-L Chen, H-L Liu, J-J Wang, “Significant temporal evolution of diffusion anisotropy for evaluating of early response to radiosurgery in patients with vestibular schwannoma: findings from functional diffusion maps,”American Journal of Neuroradiology, Vol. 31, pp. 269-274, 2010. (IF=3.464) 32. H-L Liu, Y-Y Wai, P-H Hsu, L-A Lyu, J-S Wu, C-R Shen, J-C Chen, T-C Yen, and J-J Wang, “In Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood–brain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study,” Journal of Cerebral Blood Flow & Metabolism, Vol. 30, pp. 168-177, 2010 (IF=4.522, 53/237 in “Neuroscience”). 33. J-J Wang, Y-Y Wai, Y-H Weng, K-K Ng, Y-Z Huang; L. Ying, H-L Liu, and C-H Wang, “Functional MRI in the assessment of cortical activation during gait-related imaginary tasks,”Journal of Neural Transmission, Vol. 116, pp. 1087 – 1092, 2009 (IF=2.597, 63/156). 34. H-L Liu, M-L Li, T-C Shih, S-M Huang, I-Y Lu, D-Y Lin, S-M Lin and K-C Ju, "Instantaneous Frequency Based Ultrasonic Temperature Estimation during Focused Ultrasound Thermal Therapy," Ultrasound in Medicine and Biology, Vol. 35, No. 10, pp. 1647-1661, 2009 (IF=2.493, 4/29 in“Acoustics”). 35. K-J Lin, H-L Liu**, P-H Hsu, Y-H Chung,W-C Huang, J-C Chen, S-P Wey, T-C Yen, I-T Hsiao, “Quantitative microSPECT/CT for detecting focused ultrasound induced blood-brain barrier opening in the rat,” Nuclear Medicine and Biology, Vol. 36, No. 7, pp. 853-867, 2009 (**共同第一作者, IF=2.62, 35/111 in “Radiology”). 36. H-L Liu and C-M Hsieh, "Single-Transducer Dual-Frequency Ultrasound Generation to Enhance Acoustic Cavitation," Ultrasononics Sonochemistry, Vol. 16, No. 3, pp. 431-438, 2009 (IF=3.199,2/29 in “Acoustics”). 37. H-L Liu, P-H Hsu, P-J Ju, Y-Y Wai, J-C Chen, C-R Shen, T-C Yen, and J-J Wang, "Magnetic Resonance Imaging Enhanced by Superparamagnetic Iron Oxide Particles: Usefulness for Distinguishing Between Focused Ultrasound-Induced Blood-Brain Barrier Disruption and Brain Hemorrhage," Journal of Magnetic Resonance Imaging, Vol. 29, No. 1, pp. 31-38, 2009 (IF=2.747, 37/111 in “Radiology”). 38. H-L Liu, H-W Chen, Z-H Kuo, and W-C Huang, “Design and Experimental Evaluations of a Low-Frequency Hemispherical Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Disruption” IEEE Transactions on Biomedical Engineering, Vol.55, No. 10, pp. 2407-2416., 2008 (IF=1.782, 32/69 in “Engineering, Biomedical”). 39. J-J Wang, Y-C Lin, Y-Y Wai, H-L Liu, C-P Lin, Y-Z Huang, “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach,” Magn. Reson Med., Vol. 59, No. 4, pp.764-770, 2008 (IF=3.267, 17/111 in “Radiology”). 40. H-L Liu, Y-Y Wai, W-S Chen, J-C Chen, P-H Hsu, X-Y W, W-C Huang, T-C Yen, and J-J Wang, “Hemorrhage Detection during Focused-Ultrasound Induced Blood–Brain-Barrier Opening by Using Susceptibility-Weighted Magnetic Resonance Imaging,” Ultrasound in Medicine & Biology, Vol. 34, No. 4, pp. 598-606, 2008 (IF=2.493, 4/29 in “Acoustics”). 41. T-C Shih, H-L Liu, K-C Ju, C-S Huang, P-Y Chen, H-W Huang, Y-J Ho, “The feasibility of heating on tumor periphery by using high intensity focused ultrasound thermal surgery,” Int. Comm. Heat Mass Trans., Vol. 35, pp. 439-445, 2008 (IF=1.609, 7/107). 42. H-L Liu, H Chang, W-S Chen, T-C Shih, J-K Hsiao, and W-L Lin, “Feasibility of Transrib Focused Ultrasound Thermal Ablation for Liver Tumors Using a Spherically Curved 2D Array: A Numerical Study,” Medical Physics, Vol. 34, No. 9, pp. 3436-3448, 2007(IF=3.07, 27/111 in “Radiology”). 43. H-L Liu , T-C Shih , W-S Chen and K-C Ju,“A Novel Strategy to Increase Heating Efficiency in a Split-Focus Ultrasound Phased Array,” Medical Physics, Vol. 34, No. 7, pp. 2957-2967, 2007 (IF=3.07, 27/111 in “Radiology”). 44. H-L Liu, W-L Lin, and Y-Y Chen , “A Fast and Conformal Heating Scheme for Producing Large Thermal Lesions Using a 2-D Ultrasound Phased Array,” International Journal of Hyperthermia, Vol. 23, No. 1, pp. 69 – 82, 2007 (IF=2.929, 31/111 in “Radiology”). 45. H-L Liu, Y-Y Chen, W-S Chen, T-C Shih, J-S Chen, and W-L Lin, "Interactions between consecutive sonications for characterizing the thermal mechanism in focused ultrasound therapy,” Ultrasound in Medicine & Biology, Vol. 32, No. 9, pp. 1411 – 1421, 2006(IF=2.493, 4/29 in “Acoustics”). 46. Y-S Tung, H-L Liu, C-C Wu, K-C Ju, W-S Chen, and W-L Lin, “Contrast-agent enhanced ultrasound thermal ablation,” Ultrasound in Medicine & Biology, Vol. 32, No. 7, pp. 1103 – 1110, 2006 (IF=2.493, 4/29 in “Acoustics”). 47. W-S Chen, C-C Wu, S-Y Fang, H-L Liu* (Corresponding author), “Differences in the lesion formation process between focused ultrasound and microwave ablations,” Medical Physics, Vol. 33, No. 5, pp. 1346-1351, 2006 (IF=3.07, 27/111 in “Radiology”). 48. H-L Liu, W-S Chen, J-S Chen, T-C Shih, Y-Y Chen, and W-L Lin, "Cavitation - Enhanced Ultrasound Thermal Therapy by Combined Low- and High-Frequency Ultrasound Exposure,” Ultrasound in Medicine & Biology, Vol. 32, No. 5, pp. 759-767, 2006 (SCI IF:2.021, 4/29 in“Acoustics”). 49. T-C Shih, H-L Liu, and Allen T-L Horng, “Cooling effect of thermally significant blood vessels in perfused tumor tissue during thermal therapy,” Int. Comm. Heat Mass Trans.,Vol. 33, pp. 135-141, 2006 (IF=1.609, 7/107). 50. W-S Chen, P-M Ma, H-L Liu, C-K Yeh, M-S Chen, and C-W Chang, "A novel method for estimating the focal size of two confocal high-intensity focused ultrasound transducers," J. Acoust. Soc. Am., Vol. 117, No. 6, pp.3740-3749, 2005 (IF=1.644, 6/29 in “Acoustics”). 51. H-L Liu, Nathan McDannold, and K. Hynynen, “Focal beam distortion and treatment planning in abdominal focused ultrasound surgery,” Medical Physics, Vol. 32, pp.1270-1280, 2005 (IF=3.07, 27/111 in “Radiology”). 52. H-L Liu, Y-Y Chen, J-Y Yen and W-L Lin, “A Pilot Point Temperature Regulation for Thermal Dose Control during Ultrasound Thermal Therapy,” Medical & Biological Engineering & Computing, Vol. 42, pp. 178-188, 2004 (IF=1.791, 31/69 in “Engineering, Biomedical”). 53. H-L Liu, Y-Y Chen, J-Y Yen, W-L Lin, “Thermal lesion formation and determination in external ultrasound thermal therapy,” Biomedical Engineering – Applications, Basis, and Communications, Vol. 15, No. 3, pp. 124-132, 2003 (EI ). 54. H-L Liu, Y-Y Chen, J-Y Yen and W-L Lin, “Treatment time reduction for large thermal lesions by using a multiple 1-d ultrasound phased array system,” Physics in Medicine and Biology, Vol. 48, pp.1173-1190, 2003 (IF=3.056, 11/69 in “Engineering, Biomedical”). 55. W-L Lin, T-C Liang, J-Y Yen, H-L Liu and Y-Y Chen, “Optimization of power deposition and a heating strategy for ultrasound thermal therapy,” Medical Physics, Vol. 28, No. 10, pp. 2172-2181, 2001 (IF=3.07, 27/111 in “Radiology”). 56. Y-Y Chen, W-L Lin, H-L Liu, J-Y Yen and M-J Shieh, “Self-tuning fuzzy logic control for ultrasound hyperthermia with reference temperature based on objective functions,” Medical Physics, Vol. 26, No. 5, pp. 825-833, 1999 (IF=3.07, 27/111 in “Radiology”). (B) 專利 1. H-L Liu et al, “Biomedical Used Multiple-Channel Hemispherical Focused Ultrasound Phased Array Apparatus, U. S. Patent, to be disclosed, 2012. 2. H-L Liu, I-Y Lu and S-M Huang, "Method and apparatus for real-time temperature measuring for high-intensity focused ultrasound (HIFU) therapy system," U. S. Patent, to be disclosed, 2012. 3. H-L Liu, W-S Chen, and C-K Jan, “Precision Method and Apparatus for Controlling the Shape Memory Alloy,” U.S. Patent US8046994, Nov. 01, 2011. 4. W-S Chen, H-L Liu, Y-T Huang, C-C Ma, W-B Tsai, W-P Shih, C-A Dai, “Artificial sphincter system,” US Patent No. 7955389, June 7, 2011, 2011. 5. H-L Liu and Chao-Ming Hsieh, “Multiple frequency driven ultrasound device,” US PatentNo. 7,530,272, May. 12, 2009. 6. 劉浩澧、陳文翔、詹程凱,，”一種形狀記憶合金的控制器裝置和控制方法,” 中華民國(發明), to be disclosed, 2012. 7. 陳文翔、劉浩澧、黃彥棟、馬劍清、蔡偉博、施文彬、戴子安，“人工括約肌系統,” 中華民國(發明), 專利號I351271, Nov. 11, 2011. 8. 劉浩澧、謝兆鳴, “多頻驅動單一換能器之超音波系統及訊號產生裝置”, 中華民國(發明), 專利號I323196, April 11, 2010. 9. 劉浩澧、郭鎮豪、陳恆文，“生物醫療用半圓頭罩式超音波相位陣列裝置,” 中華民國(發明), 專利號I337087, Feb. 11, 2011. |
